TNKS-2-IN-1

• CAT Number: I040671
• CAS Number: 4765-59-7
• Molecular Formula: C14H9N3O3
• Molecular Weight: 267.24
• Purity: ≥95%
• Synonyms: 2-(4-nitrophenyl)-3H-quinazolin-4-one
• InChI: InChI=1S/C14H9N3O3/c18-14-11-3-1-2-4-12(11)15-13(16-14)9-5-7-10(8-6-9)17(19)20/h1-8H,(H,15,16,18)
• InChIKey: PDSXUXCWTDUVSZ-UHFFFAOYSA-N
• SMILES: C1=CC=C2C(=C1)C(=O)NC(=N2)C3=CC=C(C=C3)[N+](=O)[O-]

TNKS-2-IN-1 (Compound 13g) is a TNKS-2 inhibitor. TNKS-2-IN-1 inhibits TNKS-1 and TNKS-2 with IC50s of 259 nM and 1100 nM[1].

Reference

[1]. Nathubhai A, et al. Structure-activity relationships of 2-arylquinazolin-4-ones as highly selective and potent inhibitors of the tankyrases. Eur J Med Chem. 2016 Aug 8;118:316-27.
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