For research use only. Not for therapeutic Use.
TNKS-2-IN-1(CAT: I040671) is a selective small-molecule inhibitor of Tankyrase 2 (TNKS2), a PARP family enzyme involved in Wnt/β-catenin signaling, telomere maintenance, and mitotic spindle regulation. By blocking TNKS2 activity, this compound stabilizes AXIN proteins, leading to the suppression of β-catenin signaling—a pathway frequently dysregulated in cancers. TNKS-2-IN-1 is widely used in oncology research to investigate Wnt-dependent tumor growth and in studies exploring stem cell differentiation and tissue regeneration. With strong potency, high selectivity, and good cell permeability, TNKS-2-IN-1 is an ideal tool for pathway analysis, target validation, and the development of new therapeutic strategies against Wnt-driven diseases.
| CAS Number | 4765-59-7 |
| Synonyms | 2-(4-nitrophenyl)-3H-quinazolin-4-one |
| Molecular Formula | C14H9N3O3 |
| Purity | ≥95% |
| IUPAC Name | C1=CC=C2C(=C1)C(=O)NC(=N2)C3=CC=C(C=C3)[N+](=O)[O-] |
| InChI | InChI=1S/C14H9N3O3/c18-14-11-3-1-2-4-12(11)15-13(16-14)9-5-7-10(8-6-9)17(19)20/h1-8H,(H,15,16,18) |
| InChIKey | PDSXUXCWTDUVSZ-UHFFFAOYSA-N |
| SMILES | C1=CC=C2C(=C1)C(=O)NC(=N2)C3=CC=C(C=C3)[N+](=O)[O-] |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
