For research use only. Not for therapeutic Use.
Tocladesine is a cyclic adenosine monophosphate (cAMP) receptor agonist potentially for the treatment of colorectal cancer.
| Catalog Number | I009841 |
| CAS Number | 41941-56-4 |
| Synonyms | 8-Cl-cAMP; ICN-1256; NSC-614491; CN1256; NSC614491; CN 1256; NSC 614491;8-Chloroadenosine 3/’,5/’-monophosphate |
| Molecular Formula | C10H11ClN5O6P |
| Purity | ≥95% |
| Target | TGF-beta/Smad |
| Solubility | Soluble in DMSO |
| Storage | 0 - 4 °C for short term, or -20 °C for long term |
| SMILES | O[C@@H]([C@H](N1C(Cl)=NC2=C(N=CN=C21)N)O3)[C@H]4[C@H]3COP(O4)(O)=O |
| Reference | </br>1: Choi KY, Cho YJ, Kim JS, Ahn YH, Hong SH. SHC1 sensitizes cancer cells to the 8-Cl-cAMP treatment. Biochem Biophys Res Commun. 2015 Aug 7;463(4):673-8. doi: 10.1016/j.bbrc.2015.05.123. PubMed PMID: 26043699. </br>2:Choi KY, Ahn YH, Ahn HW, Cho YJ, Hong SH. Involvement of Akt2/protein kinase B β (PKBβ) in the 8-Cl-cAMP-induced cancer cell growth inhibition. J Cell Physiol. 2013 Apr;228(4):890-902. doi: 10.1002/jcp.24240. PubMed PMID: 23018889.</br>3:Bajic V, Stanimirovic Z, Stevanovic J, Spremo-Potparevic B, Zivkovic L, Milicevic Z. Cytogenetic effects of 8-Cl-cAMP on human and animal chromosomes. J BUON. 2009 Jan-Mar;14(1):71-7. PubMed PMID: 19373950. |
