For research use only. Not for therapeutic Use.
Tocladesine（Cat No.:I009841）is a synthetic purine nucleoside analogue and a potent inhibitor of adenosine deaminase (ADA), an enzyme that catalyzes the conversion of adenosine to inosine. By inhibiting ADA, tocladesine increases adenosine levels, which can have various effects on immune regulation, cell signaling, and apoptosis. It has been studied for its potential therapeutic applications in treating conditions like immunodeficiencies and certain cancers, as well as in modulating inflammatory responses. However, its use in clinical practice is limited, and further research is needed to assess its safety, efficacy, and broader therapeutic applications.
| Catalog Number | I009841 |
| CAS Number | 41941-56-4 |
| Synonyms | 8-Cl-cAMP; ICN-1256; NSC-614491; CN1256; NSC614491; CN 1256; NSC 614491;8-Chloroadenosine 3/’,5/’-monophosphate |
| Molecular Formula | C10H11ClN5O6P |
| Purity | ≥95% |
| Target | TGF-beta/Smad |
| Solubility | Soluble in DMSO |
| Storage | 0 - 4 °C for short term, or -20 °C for long term |
| IUPAC Name | (4aR,6R,7R,7aS)-6-(6-amino-8-chloropurin-9-yl)-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol |
| InChI | InChI=1S/C10H11ClN5O6P/c11-10-15-4-7(12)13-2-14-8(4)16(10)9-5(17)6-3(21-9)1-20-23(18,19)22-6/h2-3,5-6,9,17H,1H2,(H,18,19)(H2,12,13,14)/t3-,5-,6-,9-/m1/s1 |
| InChIKey | CLLFEJLEDNXZNR-UUOKFMHZSA-N |
| SMILES | C1[C@@H]2[C@H]([C@H]([C@@H](O2)N3C4=NC=NC(=C4N=C3Cl)N)O)OP(=O)(O1)O |
| Reference | </br>1: Choi KY, Cho YJ, Kim JS, Ahn YH, Hong SH. SHC1 sensitizes cancer cells to the 8-Cl-cAMP treatment. Biochem Biophys Res Commun. 2015 Aug 7;463(4):673-8. doi: 10.1016/j.bbrc.2015.05.123. PubMed PMID: 26043699. </br>2:Choi KY, Ahn YH, Ahn HW, Cho YJ, Hong SH. Involvement of Akt2/protein kinase B β (PKBβ) in the 8-Cl-cAMP-induced cancer cell growth inhibition. J Cell Physiol. 2013 Apr;228(4):890-902. doi: 10.1002/jcp.24240. PubMed PMID: 23018889.</br>3:Bajic V, Stanimirovic Z, Stevanovic J, Spremo-Potparevic B, Zivkovic L, Milicevic Z. Cytogenetic effects of 8-Cl-cAMP on human and animal chromosomes. J BUON. 2009 Jan-Mar;14(1):71-7. PubMed PMID: 19373950. |
