For research use only. Not for therapeutic Use.
Toddaculin is a natural coumarin that can induce differentiation and apoptosis in leukemic cells. Toddaculin suppresses excess osteoclast activity and enhances osteoblast differentiation and mineralization. Toddaculin also exhibits anti-inflammatory activity[1][2][3].
Toddaculin (5-250 μM; 24-72 h) shows anti-proliferative activity in U-937 cells, with an IC50 of 51.38 μM[1].
Toddaculin (25-250 μM; 24-48 h) induces partial differentiation in U-937 leukemic cells[1].
| Catalog Number | I044793 |
| CAS Number | 4335-12-0 |
| Synonyms | 5,7-dimethoxy-6-(3-methylbut-2-enyl)chromen-2-one |
| Molecular Formula | C16H18O4 |
| Purity | ≥95% |
| InChI | InChI=1S/C16H18O4/c1-10(2)5-6-11-13(18-3)9-14-12(16(11)19-4)7-8-15(17)20-14/h5,7-9H,6H2,1-4H3 |
| InChIKey | KRQHZFHWEAJPNO-UHFFFAOYSA-N |
| SMILES | CC(=CCC1=C(C=C2C(=C1OC)C=CC(=O)O2)OC)C |
| Reference | [1]. Vázquez R, et, al. Toddaculin, a natural coumarin from Toddalia asiatica, induces differentiation and apoptosis in U-937 leukemic cells. Phytomedicine. 2012 Jun 15;19(8-9):737-46. [2]. Watanabe A, et, al. Toddaculin, Isolated from of Toddalia asiatica (L.) Lam., Inhibited Osteoclastogenesis in RAW 264 Cells and Enhanced Osteoblastogenesis in MC3T3-E1 Cells. PLoS One. 2015 May 18;10(5):e0127158. [3]. Kumagai M, et, al. Evaluation of Aculeatin and Toddaculin Isolated from Toddalia asiatica as Anti-inflammatory Agents in LPS-Stimulated RAW264 Macrophages. Biol Pharm Bull. 2018;41(1):132-137. |
