Toddalolactone

• CAT Number: R024505
• CAS Number: 483-90-9
• Molecular Formula: C16H20O6
• Molecular Weight: 308.33
• Purity: ≥95%
• Synonyms: 6-[(2R)-2,3-dihydroxy-3-methylbutyl]-5,7-dimethoxychromen-2-one
• InChI: InChI=1S/C16H20O6/c1-16(2,19)13(17)7-10-11(20-3)8-12-9(15(10)21-4)5-6-14(18)22-12/h5-6,8,13,17,19H,7H2,1-4H3/t13-/m1/s1
• InChIKey: GLWPLQBQHWYKRK-CYBMUJFWSA-N
• SMILES: CC(C)(C(CC1=C(C=C2C(=C1OC)C=CC(=O)O2)OC)O)O

Toddalolactone, a main component of Toddalia asiatica, inhibits the activity of recombinant human plasminogen activator inhibitor-1 (PAI-1), with an IC50 value of 37.31 μM[1].
Toddalolactone, a natural coumarin, inhibits PAI-1 activity by preventing the formation of a stable PAI-1/uPA covalent complex, suggesting that the inhibitory effect of Toddalolactone may be due to the interference of close contact between plasminogen activator and the active center of PAI-1[1].

Reference

[1]. Yu B, et al. Inhibition of PAI-1 Activity by Toddalolactone as a Mechanism for Promoting Blood Circulation and Removing Stasis by Chinese Herb Zanthoxylum nitidum var. tomentosum. Front Pharmacol. 2017 Jul 21;8:489.
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