For research use only. Not for therapeutic Use.
Todralazine (hydrochloride) is a β<sub>2</sub>-adrenergic receptor antagonist with peripheral vasodilator activity. Administration of todralazine (5 µM) to pre-larval zebrafish led to hematopoietic cell expansion and protection from ionizing radiation. It inhibited histone acetylation <em>in vitro</em> and, long-term (4 months), but not short-term (1 month), treatment in mice (3 mg/day) impaired hepatocyte histone acetylation and liver regeneration.
| Catalog Number | R066869 |
| CAS Number | 3778-76-5 |
| Synonyms | Apirachol;Binazine;Ecarazine |
| Molecular Formula | C11H13ClN4O2 |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Storage | -20°C |
| IUPAC Name | ethyl N-(phthalazin-1-ylamino)carbamate;hydrochloride |
| InChI | InChI=1S/C11H12N4O2.ClH/c1-2-17-11(16)15-14-10-9-6-4-3-5-8(9)7-12-13-10;/h3-7H,2H2,1H3,(H,13,14)(H,15,16);1H |
| InChIKey | OMCOKCNIYWULQH-UHFFFAOYSA-N |
| SMILES | CCOC(=O)NNC1=NN=CC2=CC=CC=C21.Cl |
| Reference | 1.Falase, A.O. and Salako, L.A. β-Adrenoceptor blockers in the treatment of hypertension. Afr. J. Med. Med. Sci. 8(1-2), 13-18 (1979). |
