TOK-8801

• CAT Number: I020390
• CAS Number: 105963-46-0
• Molecular Formula: C₁₇H₂₁N₃OS
• Molecular Weight: 315.43
• Purity: ≥95%

TOK-8801 (Cat No.: I020390) is a small-molecule inhibitor targeting the STAT3 (Signal Transducer and Activator of Transcription 3) signaling pathway, which is frequently dysregulated in various cancers. By blocking STAT3 phosphorylation and dimerization, TOK-8801 interferes with the transcription of genes involved in cell proliferation, survival, and immune evasion. It has shown potential in preclinical studies for reducing tumor growth and enhancing immune responses. TOK-8801 is primarily used in cancer research to explore STAT3 as a therapeutic target and evaluate novel anticancer strategies.

Reference

[1]. Fujiwara M, et al. Immunomodulatory activity of the newly synthesized compound TOK-8801 (N-(2-phenylethyl)-3,6,6-trimethyl-5,6-dihydroimidazo[2,1-b]thiazole-2- carboxamide). Jpn J Pharmacol. 1989 Dec;51(4):549-54.[2]. Shibata K, et al. Immunomodulatory effect of a newly synthesized compound, TOK-8801 (N-(2-phenylethyl)-3,6,6-trimethyl-5,6-dihydroimidazo [2,1-b]thiazole-2-carboxamide) on antibody production in vivo and delayed-type hypersensitivity in mice. Int J Immunopharmacol. 1990;12(5):497-502.