For research use only, not for therapeutic use.
Tolazamide（Cat No.:I000571） is an oral medication commonly prescribed for individuals with Type 2 diabetes. It belongs to the class of drugs known as sulfonylureas, which work by stimulating the release of insulin from the pancreas and improving insulin sensitivity in peripheral tissues. By lowering blood glucose levels, tolazamide helps to manage and control diabetes.
| Catalog Number | I000571 |
| CAS Number | 1156-19-0 |
| Molecular Formula | C14H21N3O3S |
| Purity | ≥95% |
| Solubility | DMSO:42mg/mL |
| Storage | Room Temperature |
| IUPAC Name | 1-(azepan-1-yl)-3-(4-methylphenyl)sulfonylurea |
| InChI | InChI=1S/C14H21N3O3S/c1-12-6-8-13(9-7-12)21(19,20)16-14(18)15-17-10-4-2-3-5-11-17/h6-9H,2-5,10-11H2,1H3,(H2,15,16,18) |
| InChIKey | OUDSBRTVNLOZBN-UHFFFAOYSA-N |
| SMILES | CC1=CC=C(C=C1)S(=O)(=O)NC(=O)NN2CCCCCC2 |
| Reference | </br>1:Isoenergetic Polymorphism: The Puzzle of Tolazamide as a Case Study. Boldyreva EV, Arkhipov SG, Drebushchak TN, Drebushchak VA, Losev EA, Matvienko AA, Minkov VS, Rychkov DA, Seryotkin YV, Stare J, Zakharov BA.Chemistry. 2015 Oct 19;21(43):15395-404. doi: 10.1002/chem.201501541. Epub 2015 Sep 4. PMID: 26337712 </br>2:Drug-polymer interactions at water-crystal interfaces and implications for crystallization inhibition: molecular dynamics simulations of amphiphilic block copolymer interactions with tolazamide crystals. Gao Y, Olsen KW.J Pharm Sci. 2015 Jul;104(7):2132-41. doi: 10.1002/jps.24442. Epub 2015 Jun 4. PMID: 26045147 </br>3:Altering therapy of type II diabetes mellitus from insulin to tolazamide increases blood pressure in spite of weight loss. Schmitt JK, Johns SB.Am J Hypertens. 1995 May;8(5 Pt 1):520-3. PMID: 7662230 </br>4:Adjunctive use of tolazamide in newly-diagnosed diabetic children. Sanders R, Faro B, Stoler P, Mick GJ, McCormick KL.Horm Metab Res. 1990 Nov;22(11):576-80. PMID: 2272604 </br>5:An unusual ring contraction in the formation of N-nitrosohexamethyleneimine and N-nitrosopiperidine from tolazamide. Eshraghi J, Longo J, Dalton DR, Harrington GW.Jpn J Cancer Res. 1990 Apr;81(4):324-6. PMID: 2114386 </br>6:Lichenoid drug eruption from chlorpropamide and tolazamide. Franz CB, Massullo RE, Welton WA.J Am Acad Dermatol. 1990 Jan;22(1):128-9. No abstract available. PMID: 2137135 </br>7:Improved metabolic control in insulin-dependent diabetes mellitus with insulin and tolazamide. Kabadi UM, Birkenholz MR.Arch Intern Med. 1988 Aug;148(8):1745-9. PMID: 3041937 </br>8:Glyburide and glipizide in treatment of diabetic patients with secondary failures to tolazamide or chlorpropamide. Lev JD, Zeidler A, Kumar D.Diabetes Care. 1987 Nov-Dec;10(6):679-82. PMID: 3123183 </br>9:Effects of tolazamide and exogenous insulin on pattern of postprandial carbohydrate metabolism in patients with non-insulin-dependent diabetes mellitus. Results of randomized crossover trial. Firth R, Bell P, Marsh M, Rizza RA.Diabetes. 1987 Oct;36(10):1130-8. PMID: 3308584 </br>10:Combined therapy of insulin and tolazamide decreases insulin requirement and serum triglycerides in obese patients with noninsulin-dependent diabetes mellitus. Kitabchi AE, Soria AG, Radparvar A, Lawson-Grant V.Am J Med Sci. 1987 Jul;294(1):10-4. PMID: 3605188 |
