For research use only. Not for therapeutic Use.
Tolcapone（Cat No.:A000380）is a potent inhibitor of catechol-O-methyltransferase (COMT), used in the treatment of Parkinson’s disease to improve motor symptoms. By inhibiting COMT, tolcapone reduces the breakdown of dopamine, particularly in the brain, thus enhancing and prolonging dopamine availability when combined with other treatments like levodopa. This mechanism helps alleviate Parkinsonian symptoms by stabilizing dopamine levels, crucial for motor control. Due to its effect on dopamine metabolism, tolcapone is also studied in neurological research, though it requires monitoring for potential liver-related side effects in clinical settings.
| Catalog Number | A000380 |
| CAS Number | 134308-13-7 |
| Synonyms | 134308-13-7; Tasmar; Ro 40-7592; (3,4-Dihydroxy-5-nitrophenyl)(4-methylphenyl)methanone; (3,4-dihydroxy-5-nitrophenyl)(p-tolyl)methanone |
| Molecular Formula | C14H11NO5 |
| Purity | ≥95% |
| Target | Transferase |
| Solubility | >12mg/mL in DMSO |
| Storage | -20°C |
| IUPAC Name | (3,4-dihydroxy-5-nitrophenyl)-(4-methylphenyl)methanone |
| InChI | InChI=1S/C14H11NO5/c1-8-2-4-9(5-3-8)13(17)10-6-11(15(19)20)14(18)12(16)7-10/h2-7,16,18H,1H3 |
| InChIKey | MIQPIUSUKVNLNT-UHFFFAOYSA-N |
| SMILES | CC1=CC=C(C=C1)C(=O)C2=CC(=C(C(=C2)O)O)[N+](=O)[O-] |
| Reference | 1: Mak A, Kato R, Weston K, Hayes A, Uetrecht J. An Impaired Immune Tolerance 2: Bhakta SG, Light GA, Talledo JA, Balvaneda B, Hughes E, Alvarez A, Rana BK, <br> 4: Maser T, Rich M, Hayes D, Zhao P, Nagulapally AB, Bond J, Saulnier Sholler G. 5: Kayser AS, Vega T, Weinstein D, Peters J, Mitchell JM. Right inferior frontal <br> 7: Detrait ER, Carr GV, Weinberger DR, Lamberty Y. Brain 8: Sant/’Anna R, Gallego P, Robinson LZ, Pereira-Henriques A, Ferreira N, Pinheiro 9: Longo DM, Yang Y, Watkins PB, Howell BA, Siler SQ. Elucidating Differences in <br> |
