Tolfenamic Acid

• CAT Number: A000364
• CAS Number: 13710-19-5
• Molecular Formula: C14H12ClNO2
• Molecular Weight: 261.7
• Purity: ≥95%
• Synonyms: 13710-19-5; Clotam; N-(3-Chloro-2-methylphenyl)anthranilic acid; 2-[(3-Chloro-2-methylphenyl)amino]benzoic Acid; Acido tolfenamico
• Target: COX
• Solubility: Soluble in DMSO > 10 mM
• Storage: -20°C
• InChI: 1S/C14H12ClNO2/c1-9-11(15)6-4-8-12(9)16-13-7-3-2-5-10(13)14(17)18/h2-8,16H,1H3,(H,17,18)
• InChIKey: YEZNLOUZAIOMLT-UHFFFAOYSA-N
• SMILES: CC1=C(C=CC=C1Cl)NC2=CC=CC=C2C(=O)O

Tolfenamic acid, also known as Clotam, is a non-steroidal anti-inflammatory agent. Tolfenamic acid interferes with synthesis of β-amyloid precursor protein, and thus Aβ peptides, by promoting degradation of an essential transcription factor. Tolfenamic acid has been shown to exhibit anti-cancer activities in several types of cancer.

Reference

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