Tolonidine

• CAT Number: I012163
• CAS Number: 4201-22-3
• Molecular Formula: C10H12ClN3
• Molecular Weight: 209.68
• Purity: ≥95%
• Synonyms: N-(2-chloro-4-methylphenyl)-4,5-dihydro-1H-imidazol-2-amine
• InChI: InChI=1S/C10H12ClN3/c1-7-2-3-9(8(11)6-7)14-10-12-4-5-13-10/h2-3,6H,4-5H2,1H3,(H2,12,13,14)
• InChIKey: KWBTZIFLQYYPTH-UHFFFAOYSA-N
• SMILES: CC1=CC(=C(C=C1)NC2=NCCN2)Cl

Tolonidine is a derivative of imidazoline. Tolonidine is orally active and has been shown to possess hypotensive and antihypertensive properties[1].
In the anesthetized dog, tolonidine administered i.v. decreases the amplitude of ventricular contractions, reduces aortic blood flow and increases peripheral vascular resistances[1].
In the bivagotomized pithed rat, tolonidine induces a long-lasting increase in blood pressure with no secondary hypotension, thus suggesting peripheral sympathomimetic properties[1].

Reference

[1]. Cosnier D, et al. Pharmacological properties of 2-(2-chloro-p-toluidino)-2-imidazoline-nitrate (tolonidine), a new antihypertensive agent. II. Action on cardiac contraction, circulatory parameters, autonomic receptors and diuresis. Arzneimittelforschung.
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