Toloxatone

• CAT Number: I012017
• CAS Number: 29218-27-7
• Molecular Formula: C11H13NO3
• Molecular Weight: 207.23
• Purity: ≥95%
• Synonyms: Toloxatone, Humoryl; Delalande 69276. Perenum.;5-(Hydroxymethyl)-3-(3-methylphenyl)-2-oxazolidinone
• Target: Monoamine Oxidase
• Solubility: Soluble in DMSO
• Storage: Store at 0-8 °C
• IUPAC Name: 5-(hydroxymethyl)-3-(3-methylphenyl)-1,3-oxazolidin-2-one
• InChI: InChI=1S/C11H13NO3/c1-8-3-2-4-9(5-8)12-6-10(7-13)15-11(12)14/h2-5,10,13H,6-7H2,1H3
• InChIKey: MXUNKHLAEDCYJL-UHFFFAOYSA-N
• SMILES: CC1=CC(=CC=C1)N2CC(OC2=O)CO

Toloxatone(CAT: I012017) is an antidepressant that was launched in 1984 in France for the treatment of depression. It functions as a selective and reversible inhibitor of monoamine oxidase A (RIMA), an enzyme responsible for breaking down neurotransmitters such as serotonin, norepinephrine, and dopamine. By inhibiting MAO-A, Toloxatone increases the availability of these neurotransmitters in the brain, enhancing mood and alleviating depressive symptoms. Its reversible and selective action reduces the risk of dietary tyramine-related side effects, offering a safer profile compared to irreversible MAO inhibitors. Toloxatone is particularly relevant in psychiatric research, providing insights into MAO-A inhibition and its therapeutic potential in mood disorders.