For research use only. Not for therapeutic Use.
Toltrazuril sulfone（Cat No.:I004592）, also known as ponazuril, is an active metabolite of toltrazuril, widely used as an antiprotozoal agent in veterinary medicine. It is particularly effective against Eimeria and Sarcocystis species, which cause coccidiosis and equine protozoal myeloencephalitis (EPM), respectively. Toltrazuril sulfone works by disrupting parasite energy metabolism, inhibiting their growth and reproduction. With its long-lasting efficacy and favorable safety profile, it is administered orally, often as a part of prophylactic or therapeutic treatment regimens. This metabolite plays a crucial role in maintaining animal health and productivity in agricultural and equine practices.
| Catalog Number | I004592 |
| CAS Number | 69004-04-2 |
| Synonyms | 1-methyl-3-(3-methyl-4-(4-((trifluoromethyl)sulfonyl)phenoxy)phenyl)-1,3,5-triazinane-2,4,6-trione |
| Molecular Formula | C18H14F3N3O6S |
| Purity | ≥95% |
| Target | Parasite |
| Solubility | DMSO: ≥ 33 mg/mL |
| Storage | Store at -20°C |
| IUPAC Name | 1-methyl-3-[3-methyl-4-[4-(trifluoromethylsulfonyl)phenoxy]phenyl]-1,3,5-triazinane-2,4,6-trione |
| InChI | InChI=1S/C18H14F3N3O6S/c1-10-9-11(24-16(26)22-15(25)23(2)17(24)27)3-8-14(10)30-12-4-6-13(7-5-12)31(28,29)18(19,20)21/h3-9H,1-2H3,(H,22,25,26) |
| InChIKey | VBUNOIXRZNJNAD-UHFFFAOYSA-N |
| SMILES | CC1=C(C=CC(=C1)N2C(=O)NC(=O)N(C2=O)C)OC3=CC=C(C=C3)S(=O)(=O)C(F)(F)F |
| Reference | </br>1:Toltrazuril sulfone sodium salt: synthesis, analytical detection, and pharmacokinetics in the horse. Dirikolu L, Karpiesiuk W, Lehner AF, Tobin T.J Vet Pharmacol Ther. 2012 Jun;35(3):265-74. doi: 10.1111/j.1365-2885.2011.01315.x. Epub 2011 Jun 17. PMID: 21679197 </br>2:Pharmacokinetics of toltrazuril and its metabolites, toltrazuril sulfoxide and toltrazuril sulfone, after a single oral administration to pigs. Lim JH, Kim MS, Hwang YH, Song IB, Park BK, Yun HI.J Vet Med Sci. 2010 Aug;72(8):1085-7. Epub 2010 Mar 24. PMID: 20332592 Free Article</br>3:Plasma disposition of toltrazuril and its metabolites, toltrazuril sulfoxide and toltrazuril sulfone, in rabbits after oral administration. Kim MS, Lim JH, Hwang YH, Park BK, Song IB, Yun HI.Vet Parasitol. 2010 Apr 19;169(1-2):51-6. doi: 10.1016/j.vetpar.2009.12.011. Epub 2009 Dec 22. PMID: 20083354 </br>4:Detection, quantifications and pharmacokinetics of toltrazuril sulfone (Ponazuril) in cattle. Dirikolu L, Yohn R, Garrett EF, Chakkath T, Ferguson DC.J Vet Pharmacol Ther. 2009 Jun;32(3):280-8. doi: 10.1111/j.1365-2885.2008.01039.x. PMID: 19646093 </br>5:Synthesis and detection of toltrazuril sulfone and its pharmacokinetics in horses following administration in dimethylsulfoxide. Dirikolu L, Karpiesiuk W, Lehner AF, Hughes C, Granstrom DE, Tobin T.J Vet Pharmacol Ther. 2009 Aug;32(4):368-78. doi: 10.1111/j.1365-2885.2008.01053.x. PMID: 19614842 </br>6:An explorative study to assess the efficacy of toltrazuril-sulfone (ponazuril) in calves experimentally infected with Neospora caninum. Kritzner S, Sager H, Blum J, Krebber R, Greif G, Gottstein B.Ann Clin Microbiol Antimicrob. 2002 Oct 18;1:4. PMID: 12437777 Free PMC Article |
