For research use only. Not for therapeutic Use.
Tomaymycin DM, a DNA alkylator, is a derivative of Tomaymycin, it is a PBD dimer, which is attached to tumor targeting antibodies to create antibody-drug conjugates (ADCs).
| Catalog Number | I043487 |
| CAS Number | 945490-09-5 |
| Synonyms | (6aS)-3-hydroxy-2-methoxy-8-methylidene-7,9-dihydro-6aH-pyrrolo[2,1-c][1,4]benzodiazepin-11-one |
| Molecular Formula | C14H14N2O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C14H14N2O3/c1-8-3-9-6-15-11-5-12(17)13(19-2)4-10(11)14(18)16(9)7-8/h4-6,9,17H,1,3,7H2,2H3/t9-/m0/s1 |
| InChIKey | GXKVYHPROGIVCL-VIFPVBQESA-N |
| SMILES | COC1=C(C=C2C(=C1)C(=O)N3CC(=C)CC3C=N2)O |
| Reference | [1]. Dr. Julia Mantaj, et al. From Anthramycin to Pyrrolobenzodiazepine (PBD)-Containing Antibody–Drug Conjugates (ADCs). Angew Chem Int Ed Engl. 2017 Jan 9; 56(2): 462–488. |
