For research use only. Not for therapeutic Use.
Tomelukast (Cat.No:I009846) is a leukotriene receptor antagonist used in the management of asthma and allergic rhinitis. By blocking the action of leukotrienes, Tomelukast helps reduce inflammation and bronchoconstriction, leading to improved respiratory symptoms. It is available in tablet form and is commonly prescribed for both adults and children with respiratory conditions.
| Catalog Number | I009846 |
| CAS Number | 88107-10-2 |
| Synonyms | Tomelukast;Ethanone, 1-(2-hydroxy-3-propyl-4-(4-(1H-tetrazol-5-yl)butoxy)phenyl)- |
| Molecular Formula | C16H22N4O3 |
| Purity | ≥95% |
| Target | Leukotriene Receptor |
| Solubility | Soluble in DMSO |
| Storage | Room temperature |
| IUPAC Name | 1-[2-hydroxy-3-propyl-4-[4-(2H-tetrazol-5-yl)butoxy]phenyl]ethanone |
| InChI | InChI=1S/C16H22N4O3/c1-3-6-13-14(9-8-12(11(2)21)16(13)22)23-10-5-4-7-15-17-19-20-18-15/h8-9,22H,3-7,10H2,1-2H3,(H,17,18,19,20) |
| InChIKey | MWYHLEQJTQJHSS-UHFFFAOYSA-N |
| SMILES | CCCC1=C(C=CC(=C1O)C(=O)C)OCCCCC2=NNN=N2 |
| Reference | </br>1: Moreno JJ. Eicosanoid receptors: Targets for the treatment of disrupted intestinal epithelial homeostasis. Eur J Pharmacol. 2016 Dec 7;796:7-19. doi: 10.1016/j.ejphar.2016.12.004. [Epub ahead of print] Review. PubMed PMID: 27940058.</br>2: Reques FG, Rodriguez JL. Tolerability of leukotriene modifiers in asthma: a review of clinical experience. BioDrugs. 1999 Jun;11(6):385-94. PubMed PMID: 18031150.</br>3: Shahbazian A, Heinemann A, Peskar BA, Holzer P. Differential peristaltic motor effects of prostanoid (DP, EP, IP, TP) and leukotriene receptor agonists in the guinea-pig isolated small intestine. Br J Pharmacol. 2002 Dec;137(7):1047-54. PubMed PMID: 12429577; PubMed Central PMCID: PMC1573581. |
