Topoisomerase II inhibitor 13

• CAT Number: I041276
• CAS Number: 451515-89-2
• Molecular Formula: C22H23N9
• Molecular Weight: 413.48
• Purity: ≥95%
• Synonyms: 6-amino-7-(1H-benzimidazol-2-yl)-5-[3-(diethylamino)propyl]pyrrolo[2,3-b]pyrazine-2,3-dicarbonitrile
• InChI: InChI=1S/C22H23N9/c1-3-30(4-2)10-7-11-31-20(25)18(21-27-14-8-5-6-9-15(14)28-21)19-22(31)29-17(13-24)16(12-23)26-19/h5-6,8-9H,3-4,7,10-11,25H2,1-2H3,(H,27,28)
• InChIKey: SZUYNNSSCOCFTF-UHFFFAOYSA-N
• SMILES: CCN(CC)CCCN1C(=C(C2=NC(=C(N=C21)C#N)C#N)C3=NC4=CC=CC=C4N3)N

Topoisomerase II inhibitor 13 is a topoisomerase II (Topo II) inhibitor. Topoisomerase II inhibitor 13 shows antiproliferative activity against several cancer cells. Topoisomerase II inhibitor 13 induces cancer cells apoptosis[1].
Topoisomerase II inhibitor 13 (compound 3m) (20 μM, 50 μM) exerts strong inhibitory effect at 20 μM, and almost completely inhibits Topo II activity[1].
Topoisomerase II inhibitor 13 inhibits cancer cells proliferation with IC50s of 25.85 μM (MDA-MB-231), 1.82 μM (A549), 10.38 μM (K562), 1.73 μM (Raji), 1.23 μM (HL-60), and 0.87 μM (HL-60/MX2), respectively[1].

Reference

[1]. Li P H, et al. Synthesis and mechanism studies of 1, 3-benzoazolyl substituted pyrrolo [2, 3-b] pyrazine derivatives as nonintercalative topoisomerase II catalytic inhibitors. Journal of Medicinal Chemistry, 2016, 59(1): 238-252.