Topotecan

• CAT Number: I000954
• CAS Number: 123948-87-8
• Molecular Formula: C23H23N3O5
• Molecular Weight: 421.45
• Purity: ≥95%
• Storage: 3 years -20°C powder
• SMILES: CCC1(C2=C(COC1=O)C(=O)N3CC4=CC5=C(C=CC(=C5CN(C)C)O)N=C4C3=C2)O

Topotecan(NSC609699,Nogitecan,SKFS 104864A) is an antineoplastic agent used to treat ovarian cancer that works by inhibiting DNA topoisomerases.

Reference

[1] Semiha Kevser Bali, et al. Biochemistry . 2018 Mar 6;57(9):1542-1551.
[2] Karimnia N, et al. J Exp Clin Cancer Res. 2021 Sep 1;40(1):276.
[3] Wang X, et al. Arthritis Rheumatol. 2021 Aug;73(8):1478-1488.