For research use only. Not for therapeutic Use.
Topotecan (Tpt)（Cat No.:M111879）is a potent topoisomerase I inhibitor used in cancer research and chemotherapy. It works by stabilizing the DNA-topoisomerase I complex, preventing DNA unwinding and leading to DNA strand breaks during replication, ultimately inducing apoptosis in rapidly dividing cells. Topotecan is effective against various cancers, including ovarian, lung, and cervical cancers. Its unique mechanism of action makes it a valuable tool for studying DNA damage responses and cancer cell resistance. Additionally, Topotecan is widely used to explore novel combination therapies in oncology, enhancing treatment outcomes.
| Catalog Number | M111879 |
| CAS Number | 139339-45-0 |
| Synonyms | Ro 24-7429 |
| Molecular Formula | C14H13ClN4 |
| Purity | ≥95% |
| Target | Apoptosis |
| Storage | -20°C |
| IUPAC Name | 7-chloro-N-methyl-5-(1H-pyrrol-2-yl)-1,3-dihydro-1,4-benzodiazepin-2-imine |
| InChI | InChI=1S/C14H13ClN4/c1-16-13-8-18-14(12-3-2-6-17-12)10-7-9(15)4-5-11(10)19-13/h2-7,17H,8H2,1H3,(H,16,19) |
| InChIKey | LEAKQIXYSHIHCW-UHFFFAOYSA-N |
| SMILES | CN=C1CN=C(C2=C(N1)C=CC(=C2)Cl)C3=CC=CN3 |
| Reference | </br>1: Patki AH, Lederman MM. HIV-1 Tat protein and its inhibitor Ro 24-7429 inhibit lymphocyte proliferation and induce apoptosis in peripheral blood mononuclear cells from healthy donors. Cell Immunol. 1996 Apr 10;169(1):40-6. PubMed PMID:8612292.</br>2: Haubrich RH, Flexner C, Lederman MM, Hirsch M, Pettinelli CP, Ginsberg R, Lietman P, Hamzeh FM, Spector SA, Richman DD. A randomized trial of the activity and safety of Ro 24-7429 (Tat antagonist) versus nucleoside for human immunodeficiency virus infection. The AIDS Clinical Trials Group 213 Team. J Infect Dis. 1995 Nov;172(5):1246-52. PubMed PMID: 7594660.</br>3: Dunne AL, Siregar H, Mills J, Crowe SM. HIV replication in chronically infected macrophages is not inhibited by the Tat inhibitors Ro-5-3335 and Ro-24-7429. J Leukoc Biol. 1994 Sep;56(3):369-73. PubMed PMID: 8083610.</br> </br> |
