For research use only. Not for therapeutic Use.
Ro 24-7429 is a Tat antagonist. Ro 24-7429 blocks the action of the HIV tat protein and is an analog of Ro 5-3335.
| Catalog Number | M111879 |
| CAS Number | 139339-45-0 |
| Synonyms | Ro 24-7429 |
| Molecular Formula | C14H13ClN4 |
| Purity | ≥95% |
| Target | Tat antagonist |
| Storage | -20°C |
| IUPAC Name | 7-chloro-N-methyl-5-(1H-pyrrol-2-yl)-3H-1,4-benzodiazepin-2-amine |
| InChI | InChI=1S/C14H13ClN4/c1-16-13-8-18-14(12-3-2-6-17-12)10-7-9(15)4-5-11(10)19-13/h2-7,17H,8H2,1H3,(H,16,19) |
| InChIKey | LEAKQIXYSHIHCW-UHFFFAOYSA-N |
| SMILES | CNC1=NC2=C(C=C(C=C2)Cl)C(=NC1)C3=CC=CN3 |
| Reference | </br>1: Patki AH, Lederman MM. HIV-1 Tat protein and its inhibitor Ro 24-7429 inhibit lymphocyte proliferation and induce apoptosis in peripheral blood mononuclear cells from healthy donors. Cell Immunol. 1996 Apr 10;169(1):40-6. PubMed PMID:8612292.</br>2: Haubrich RH, Flexner C, Lederman MM, Hirsch M, Pettinelli CP, Ginsberg R, Lietman P, Hamzeh FM, Spector SA, Richman DD. A randomized trial of the activity and safety of Ro 24-7429 (Tat antagonist) versus nucleoside for human immunodeficiency virus infection. The AIDS Clinical Trials Group 213 Team. J Infect Dis. 1995 Nov;172(5):1246-52. PubMed PMID: 7594660.</br>3: Dunne AL, Siregar H, Mills J, Crowe SM. HIV replication in chronically infected macrophages is not inhibited by the Tat inhibitors Ro-5-3335 and Ro-24-7429. J Leukoc Biol. 1994 Sep;56(3):369-73. PubMed PMID: 8083610.</br> </br> |
