Toreforant

For research use only. Not for therapeutic Use.

  • CAT Number: I009851
  • CAS Number: 952494-46-1
  • Molecular Formula: C23H32N6
  • Molecular Weight: 392.551
  • Purity: ≥95%
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Toreforant is a selective antagonist of the histamine H4 receptor, which is being investigated for its potential in treating inflammatory and allergic conditions, such as atopic dermatitis and asthma. By blocking the H4 receptor, toreforant can reduce the recruitment and activation of immune cells, leading to decreased inflammation and allergic responses. This targeted approach aims to provide therapeutic benefits with fewer side effects compared to broader-acting anti-inflammatory drugs, making toreforant a promising candidate in the treatment of chronic inflammatory diseases.


Catalog Number I009851
CAS Number 952494-46-1
Synonyms

JNJ-38518168; JNJ 38518168; JNJ38518168; Toreforant.;5-(4,6-dimethyl-1H-benzimidazol-2-yl)-4-methyl- N-[3-(1-methylpiperidin-4-yl)propyl]pyrimidin-2-amine

Molecular Formula C23H32N6
Purity ≥95%
Target Neuronal Signaling
Solubility Soluble in DMSO, not in water
Storage 0 - 4 °C for short term, or -20 °C for long term
IUPAC Name 5-(4,6-dimethyl-1H-benzimidazol-2-yl)-4-methyl-N-[3-(1-methylpiperidin-4-yl)propyl]pyrimidin-2-amine
InChI InChI=1S/C23H32N6/c1-15-12-16(2)21-20(13-15)27-22(28-21)19-14-25-23(26-17(19)3)24-9-5-6-18-7-10-29(4)11-8-18/h12-14,18H,5-11H2,1-4H3,(H,27,28)(H,24,25,26)
InChIKey FCRFVPZAXGJLPW-UHFFFAOYSA-N
SMILES CC1=CC(=C2C(=C1)NC(=N2)C3=CN=C(N=C3C)NCCCC4CCN(CC4)C)C

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