Tos-PEG2-O-Propargyl

• CAT Number: I017041
• CAS Number: 1119249-30-7
• Molecular Formula: C₁₄H₁₈O₅S
• Molecular Weight: 298.35
• Purity: ≥95%
• Target: PROTAC Linkers

Tos-PEG2-O-Propargyl (CAT: I017041) is a compound consisting of a PEG (polyethylene glycol) linker attached to an O-propargyl group, protected by a tosyl (tosylate) group. It is commonly used in bioconjugation and chemical biology research. The PEG linker provides water solubility and flexibility, allowing for efficient conjugation of the compound to various biomolecules, such as proteins or peptides. The O-propargyl group offers a reactive handle for further functionalization via click chemistry reactions, enabling the attachment of other molecules or tags.

Reference

[1]. Wurz RP, et al. A “Click Chemistry Platform” for the Rapid Synthesis of Bispecific Molecules for Inducing Protein Degradation. J Med Chem. 2018 Jan 25;61(2):453-461.