For research use only. Not for therapeutic Use.
Tos-PEG2-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
| Catalog Number | I045417 |
| CAS Number | 69502-32-5 |
| Synonyms | 2-[2-(oxan-2-yloxy)ethoxy]ethyl 4-methylbenzenesulfonate |
| Molecular Formula | C16H24O6S |
| Purity | ≥95% |
| InChI | InChI=1S/C16H24O6S/c1-14-5-7-15(8-6-14)23(17,18)22-13-11-19-10-12-21-16-4-2-3-9-20-16/h5-8,16H,2-4,9-13H2,1H3 |
| InChIKey | MYIMMUFXKWKAID-UHFFFAOYSA-N |
| SMILES | CC1=CC=C(C=C1)S(=O)(=O)OCCOCCOC2CCCCO2 |
| Reference | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
