Tos-PEG3-NH-Boc

• CAT Number: I018634
• CAS Number: 206265-94-3
• Molecular Formula: C₁₈H₂₉NO₇S
• Molecular Weight: 403.49
• Purity: ≥95%
• Target: PROTAC Linkers
• IUPAC Name: 2-[2-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate
• InChI: InChI=1S/C18H29NO7S/c1-15-5-7-16(8-6-15)27(21,22)25-14-13-24-12-11-23-10-9-19-17(20)26-18(2,3)4/h5-8H,9-14H2,1-4H3,(H,19,20)
• InChIKey: IFWYDEPNEKFVRX-UHFFFAOYSA-N
• SMILES: CC1=CC=C(C=C1)S(=O)(=O)OCCOCCOCCNC(=O)OC(C)(C)C

Tos-PEG3-NH-Boc (Cat No.:I018634) is a PEG-based PROTAC linker that is commonly utilized in the synthesis of PROTACs (proteolysis-targeting chimeras). It consists of a tosyl (Tos) group, a PEG spacer with three ethylene glycol units (PEG3), and a Boc-protected amine (NH-Boc). This linker provides stability, flexibility, and hydrophilicity to the PROTAC molecule. It allows for the conjugation of different ligands to target proteins of interest and facilitates the recruitment of E3 ligases for targeted protein degradation. The incorporation of this linker in PROTAC synthesis aids in enhancing the therapeutic potential of these compounds.

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.