Tos-PEG4-CH2-Boc

• CAT Number: I017197
• CAS Number: 169751-73-9
• Molecular Formula: C₂₁H₃₄O₉S
• Molecular Weight: 462.55
• Purity: ≥95%
• Target: PROTAC Linkers

Tos-PEG4-CH2-Boc(CAT: I017197) is a compound consisting of a tosyl-protected polyethylene glycol (PEG) linker with a Boc (tert-butyloxycarbonyl) group attached to the CH2 unit. The tosyl group provides a protecting group for further chemical modifications, while the PEG linker imparts hydrophilicity and flexibility to the molecule. The Boc group can be removed under mild acidic conditions, allowing for the introduction of functional groups or conjugation with other molecules. Tos-PEG4-CH2-Boc is specifically designed as a linker for use in the synthesis of PROTAC (PROteolysis TArgeting Chimeras) molecules, which are bifunctional molecules used for targeted protein degradation.

Reference

[1]. Snaebjornsson MT, et al. Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways. Exp Mol Med. 2018 Apr 16;50(4):34.