Tos-PEG4-CH2COOH

• CAT Number: I016991
• CAS Number: 2028284-73-1
• Molecular Formula: C₁₇H₂₆O₉S
• Molecular Weight: 406.45
• Purity: ≥95%
• Target: PROTAC Linkers

Tos-PEG4-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Reference

[1]. Snaebjornsson MT, et al. Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways. Exp Mol Med. 2018 Apr 16;50(4):34.