Tos-PEG4-CH2COOH

• CAT Number: I016991
• CAS Number: 2028284-73-1
• Molecular Formula: C₁₇H₂₆O₉S
• Molecular Weight: 406.45
• Purity: ≥95%
• Target: PROTAC Linkers
• IUPAC Name: 2-[2-[2-[2-[2-(4-methylphenyl)sulfonyloxyethoxy]ethoxy]ethoxy]ethoxy]acetic acid
• InChI: InChI=1S/C17H26O9S/c1-15-2-4-16(5-3-15)27(20,21)26-13-12-24-9-8-22-6-7-23-10-11-25-14-17(18)19/h2-5H,6-14H2,1H3,(H,18,19)
• InChIKey: MTBIBZOLTXFDIU-UHFFFAOYSA-N
• SMILES: CC1=CC=C(C=C1)S(=O)(=O)OCCOCCOCCOCCOCC(=O)O

Tos-PEG4-CH2COOH(CAT: I016991) is a versatile reagent featuring a tosyl (tos) group and a carboxylic acid functional group, linked via a polyethylene glycol (PEG4) spacer. The tosyl group serves as a reactive electrophile, allowing selective modification of nucleophilic residues, such as amines or thiols, in biomolecules. The PEG4 spacer enhances solubility and flexibility, making it ideal for bioconjugation and linker strategies in drug delivery and chemical biology research. The terminal carboxylic acid provides an additional functional handle for coupling reactions, such as amidation or esterification. Tos-PEG4-CH2COOH is widely used in the synthesis of peptide conjugates, antibody-drug conjugates, and other targeted therapeutic applications.