Tos-PEG4-NH-Boc

• CAT Number: I018636
• CAS Number: 1246999-33-6
• Molecular Formula: C₂₀H₃₃NO₈S
• Molecular Weight: 447.54
• Purity: ≥95%
• Target: PROTAC Linkers

Tos-PEG4-NH-Boc (CAT: I018636) is a PEG-based PROTAC linker, specifically designed for use in the synthesis of PROTACs. PROTACs (PROteolysis TArgeting Chimeras) are innovative molecules that work by harnessing the cell’s own machinery to selectively degrade target proteins within cells. The linker plays a crucial role in connecting the target protein binder (ligand) and the E3 ubiquitin ligase recruiting moiety, facilitating the targeted protein degradation process.

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.