Tos-PEG4-THP

For research use only. Not for therapeutic Use.

  • CAT Number: I016933
  • CAS Number: 86259-89-4
  • Molecular Formula: C₂₀H₃₂O₈S
  • Molecular Weight: 432.53
  • Purity: ≥95%
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Tos-PEG4-THP(CAT: I016933) is a crucial PEG-based linker utilized in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523). This linker plays a pivotal role in connecting the target-binding ligand with the E3 ligase ligand within the PROTAC molecule. The polyethylene glycol (PEG) spacer enhances solubility, biocompatibility, and flexibility, enabling efficient intracellular delivery and engagement of the cellular degradation machinery.


Catalog Number I016933
CAS Number 86259-89-4
Molecular Formula C₂₀H₃₂O₈S
Purity ≥95%
Target PROTAC Linkers
Reference

[1]. Andrew P. Crew, et al. Modulators of proteolysis and associated methods of use. WO2019195609A2.

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