Tos-PEG5-C2-Boc

• CAT Number: I016902
• CAS Number: 850090-10-7
• Molecular Formula: C₂₄H₄₀O₁₀S
• Molecular Weight: 520.63
• Purity: ≥95%
• Target: PROTAC Linkers

Tos-PEG5-C2-Boc (CAT: I016902) functions as a PEG-based PROTAC linker, playing a pivotal role in the synthesis of Proteolysis-Targeting Chimeras (PROTACs). These innovative molecules harness the cellular protein degradation machinery to selectively remove disease-causing proteins. Tos-PEG5-C2-Boc acts as a strategic molecular bridge, facilitating the conjugation of a ligand that binds to the target protein with a ligand that recruits an E3 ubiquitin ligase.

Reference

[1]. Snaebjornsson MT, et al. Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways. Exp Mol Med. 2018 Apr 16;50(4):34.