For research use only. Not for therapeutic Use.
Tos-PEG9(CAT: I0160190) serves as a PEG-based linker essential for constructing PROTACs (PROteolysis Targeting Chimeras). Within the structure of PROTACs, this linker facilitates the connection of two distinct ligands—one tailored for an E3 ubiquitin ligase, while the other binds to the target protein. This strategic design capitalizes on the intracellular ubiquitin-proteasome system, orchestrating the targeted degradation of specific proteins. The role of Tos-PEG9 lies in enabling the synthesis of these intricate PROTAC molecules, providing a pivotal tool for innovative drug development strategies with applications in precise protein degradation therapies.
| Catalog Number | I016019 |
| CAS Number | 62573-11-9 |
| Molecular Formula | C₂₅H₄₄O₁₂S |
| Purity | ≥95% |
| Target | PROTAC Linkers |
| Reference | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
