For research use only. Not for therapeutic Use.
TP-030-2 is a RIPK1 inhibitor (human Ki=0.43 nM; mouse IC50=100 nM)[1][2].
TP-030-2 shows inhibiton in HT29 with IC50=1.3 nM[2].
| Catalog Number | I042640 |
| CAS Number | 2095514-84-2 |
| Synonyms | (3S)-3-(2-benzyl-3-bromo-7-oxo-4,5-dihydropyrazolo[3,4-c]pyridin-6-yl)-5-methyl-2,3-dihydro-1,5-benzoxazepin-4-one |
| Molecular Formula | C23H21BrN4O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C23H21BrN4O3/c1-26-17-9-5-6-10-19(17)31-14-18(22(26)29)27-12-11-16-20(23(27)30)25-28(21(16)24)13-15-7-3-2-4-8-15/h2-10,18H,11-14H2,1H3/t18-/m0/s1 |
| InChIKey | KHVVJKLNKLQLJZ-SFHVURJKSA-N |
| SMILES | CN1C2=CC=CC=C2OCC(C1=O)N3CCC4=C(N(N=C4C3=O)CC5=CC=CC=C5)Br |
| Reference | [1]. Yoshikawa M, et al. Discovery of 7-Oxo-2,4,5,7-tetrahydro-6 H-pyrazolo[3,4- c]pyridine Derivatives as Potent, Orally Available, and Brain-Penetrating Receptor Interacting Protein 1 (RIP1) Kinase Inhibitors: Analysis of Structure-Kinetic Relationships. J Med Chem. 2018 Mar 22;61(6):2384-2409. [2]. https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/TP-030-2 |
