TP-040

• CAT Number: I045423
• CAS Number: 2757254-99-0
• Molecular Formula: C15H22N6
• Molecular Weight: 286.38
• Purity: ≥95%
• Synonyms: N-[(1-methylimidazol-4-yl)methyl]-4-(4-methylpiperidin-1-yl)pyrimidin-2-amine
• InChI: InChI=1S/C15H22N6/c1-12-4-7-21(8-5-12)14-3-6-16-15(19-14)17-9-13-10-20(2)11-18-13/h3,6,10-12H,4-5,7-9H2,1-2H3,(H,16,17,19)
• InChIKey: PWKAYICUBVNJAZ-UHFFFAOYSA-N
• SMILES: CC1CCN(CC1)C2=NC(=NC=C2)NCC3=CN(C=N3)C

TP-040 (O-GlcNAcase-IN-1) is a potent and novel OGA inhibitor with an IC50 value of 46 nM.

Reference

[1]. Tawada M, et al. Discovery of a Novel and Brain-Penetrant O-GlcNAcase Inhibitor via Virtual Screening, Structure-Based Analysis, and Rational Lead Optimization. J Med Chem. 2021 Jan 28;64(2):1103-1115.
 [Content Brief]