TP-3654

• CAT Number: I009858
• CAS Number: 1361951-15-6
• Molecular Formula: C22H25F3N4O
• Molecular Weight: 418.46
• Purity: ≥95%
• Synonyms: TP-3654; TP3654; TP 3654;2-((1r,4r)-4-((3-(3-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazin-6-yl)amino)cyclohexyl)propan-2-ol
• Target: Pim-1 & Pim-3 Kinase Inhibitor
• Solubility: Soluble in DMSO
• Storage: Store at -20°C
• IUPAC Name: 2-[4-[[3-[3-(trifluoromethyl)phenyl]imidazo[1,2-b]pyridazin-6-yl]amino]cyclohexyl]propan-2-ol
• InChI: InChI=1S/C22H25F3N4O/c1-21(2,30)15-6-8-17(9-7-15)27-19-10-11-20-26-13-18(29(20)28-19)14-4-3-5-16(12-14)22(23,24)25/h3-5,10-13,15,17,30H,6-9H2,1-2H3,(H,27,28)
• InChIKey: XRNVABDYQLHODA-UHFFFAOYSA-N
• SMILES: CC(C)(C1CCC(CC1)NC2=NN3C(=NC=C3C4=CC(=CC=C4)C(F)(F)F)C=C2)O

TP-3654（Cat No.: I009858）, is a second-generation inhibitor specifically targeting the PIM family of kinases. It exhibits potent inhibitory activity with impressive Ki values of 5 nM, 239 nM, and 42 nM against PIM-1, PIM-2, and PIM-3, respectively. This high selectivity and affinity for PIM kinases make TP-3654 a valuable tool for research related to signal transduction pathways and kinase-mediated cellular processes. Should you require additional information or assistance regarding TP-3654, please feel free to contact us.

Reference

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