For research use only. Not for therapeutic Use.
TP003 is a non-selective benzodiazepine site agonist with EC50s of 20.3, 10.6, 3.24, 5.64 nM for α1β2γ2, α2β3γ2, α3β3γ2, α5β2γ2, respectively. TP003 induces anxiolysis via α2GABAA receptors[1].
| Catalog Number | I010952 |
| CAS Number | 628690-75-5 |
| Synonyms | 5-fluoro-2-[2-fluoro-5-[8-fluoro-7-(2-hydroxypropan-2-yl)imidazo[1,2-a]pyridin-3-yl]phenyl]benzonitrile |
| Molecular Formula | C23H16F3N3O |
| Purity | ≥95% |
| InChI | InChI=1S/C23H16F3N3O/c1-23(2,30)18-7-8-29-20(12-28-22(29)21(18)26)13-3-6-19(25)17(10-13)16-5-4-15(24)9-14(16)11-27/h3-10,12,30H,1-2H3 |
| InChIKey | SJMMDWXJSSJHOQ-UHFFFAOYSA-N |
| SMILES | CC(C)(C1=C(C2=NC=C(N2C=C1)C3=CC(=C(C=C3)F)C4=C(C=C(C=C4)F)C#N)F)O |
| Reference | [1]. Elena Neumann, et al. TP003 is a non-selective benzodiazepine site agonist that induces anxiolysis via α2GABAA receptors. Neuropharmacology. 2018 Dec;143:71-78. |
