For research use only. Not for therapeutic Use.
TP0427736 is a potent inhibitor of ALK5 kinase activity with an IC50 of 2.72 nM and this effect is 300-fold higher than the inhibitory effect on ALK3 (IC50 = 836 nM for ALK3). It also inhibits Smad2/3 phosphorylation in A549 cells induced by TGF-β1 with an IC50 value of 8.68 nM.
| Catalog Number | I037422 |
| CAS Number | 864374-00-5 |
| Molecular Formula | C14H11ClN4S2 |
| Purity | ≥95% |
| Storage | 3 years -20°C powder |
| SMILES | CC1=CSC(=N1)C2=C(N=CN2)C3=CC4=C(C=C3)N=CS4 |
| Reference | [1] Naruse T, et al. Pharmacol Rep. 2017, 69(3):485-491. |
