TPBM

For research use only. Not for therapeutic Use.

  • CAT Number: I037433
  • CAS Number: 6466-43-9
  • Molecular Formula: C15H16N4O2S
  • Molecular Weight: 316.38
  • Purity: ≥95%
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TPBM is a potent estrogen receptor α (ERα) inhibitor with an IC50 value of 9 μM for 17β-estradiol (E2)-ERα. TPBM reduces E2·ERα recruitment to an endogenous estrogen-responsive gene. TPBM inhibits E2-dependent growth of ERα-positive cancer cells (IC50=5 μM). TPBM is not toxic to cells and does not affect estrogen-independent cell growth[1].


Catalog Number I037433
CAS Number 6466-43-9
Synonyms

8-(benzylsulfanylmethyl)-1,3-dimethyl-7H-purine-2,6-dione

Molecular Formula C15H16N4O2S
Purity ≥95%
InChI InChI=1S/C15H16N4O2S/c1-18-13-12(14(20)19(2)15(18)21)16-11(17-13)9-22-8-10-6-4-3-5-7-10/h3-7H,8-9H2,1-2H3,(H,16,17)
InChIKey FEHAMBYTUPDFJE-UHFFFAOYSA-N
SMILES CN1C2=C(C(=O)N(C1=O)C)NC(=N2)CSCC3=CC=CC=C3
Reference

[1]. Mao C, et al. A new small molecule inhibitor of estrogen receptor alpha binding to estrogen response elements blocks estrogen-dependent growth of cancer cells. J Biol Chem. 2008;283(19):12819-12830.
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