TPCA-1

• CAT Number: I003804
• CAS Number: 507475-17-4
• Molecular Formula: C₁₂H₁₀FN₃O₂S
• Molecular Weight: 279.29
• Purity: ≥95%
• Synonyms: 2-(carbamoylamino)-5-(4-fluorophenyl)thiophene-3-carboxamide
• Target: Stem Cell/Wnt
• Solubility: DMSO 56 mg/ml; Water <1 mg/ml
• Storage: 3 years -20C powder
• IC50: 17.9 nM
• InChI: InChI=1S/C12H10FN3O2S/c13-7-3-1-6(2-4-7)9-5-8(10(14)17)11(19-9)16-12(15)18/h1-5H,(H2,14,17)(H3,15,16,18)
• InChIKey: SAYGKHKXGCPTLX-UHFFFAOYSA-N
• SMILES: C1=CC(=CC=C1C2=CC(=C(S2)NC(=O)N)C(=O)N)F

TPCA-1(CAT: I003804) is a potent and selective inhibitor of IκB kinase 2 (IKK-2 or IKKβ), a key regulator of the NF-κB signaling pathway. By blocking IKKβ, TPCA-1 prevents the phosphorylation and degradation of IκBα, thereby inhibiting the activation of NF-κB and reducing the expression of pro-inflammatory cytokines and survival genes. This mechanism makes TPCA-1 highly valuable in inflammation and immunology research, particularly for studying inflammatory diseases, autoimmune disorders, and cancer. Its ability to modulate NF-κB signaling offers therapeutic potential in targeting chronic inflammation and tumor progression.