TPI-287

• CAT Number: I009862
• CAS Number: 849213-15-6
• Molecular Formula: C46H63NO15
• Molecular Weight: 869.99
• Purity: ≥95%
• Synonyms: TPI287; TPI-287; TPI 287; ARC100; ARC-100; ARC 100; NBT-287; NBT287; NBT 287;(1S,2S,4S,7S,7aR,7a1S,10aS,11aR,13aS,13bR)-1-(benzoyloxy)-4-(((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-5-methylhexanoyl)oxy)-2-hydroxy-5,7a1,14,14-tetramethyl-9-viny
• Target: Cytoskeleton
• Solubility: Soluble in DMSO, not in water
• Storage: 0 - 4 °C for short term, or -20 °C for long term
• IUPAC Name: [(1R,2S,5R,7S,11R,12S,15S,17S,18S,19S)-2,12-diacetyloxy-9-ethenyl-17-hydroxy-15-[(2R,3S)-2-hydroxy-5-methyl-3-[(2-methylpropan-2-yl)oxycarbonylamino]hexanoyl]oxy-14,19,20,20-tetramethyl-4,8,10-trioxapentacyclo[9.7.1.113,17.02,5.07,19]icos-13-en-18-yl] benzoate
• InChI: InChI=1S/C46H63NO15/c1-13-32-58-30-20-31-45(22-55-31,61-26(6)49)36-38(60-39(51)27-17-15-14-16-18-27)46(54)21-29(57-40(52)34(50)28(19-23(2)3)47-41(53)62-42(7,8)9)24(4)33(43(46,10)11)35(56-25(5)48)37(59-32)44(30,36)12/h13-18,23,28-32,34-38,50,54H,1,19-22H2,2-12H3,(H,47,53)/t28-,29-,30-,31+,32?,34+,35-,36-,37-,38-,44+,45-,46+/m0/s1
• InChIKey: FDTAUJJRHBRHIJ-FDJAAIFISA-N
• SMILES: CC1=C2[C@@H]([C@H]3[C@@]4([C@H](C[C@@H]5[C@]([C@H]4[C@@H]([C@@](C2(C)C)(C[C@@H]1OC(=O)[C@@H]([C@H](CC(C)C)NC(=O)OC(C)(C)C)O)O)OC(=O)C6=CC=CC=C6)(CO5)OC(=O)C)OC(O3)C=C)C)OC(=O)C

TPI-287（Cat No.:I009862）is a small molecule drug that functions as a microtubule stabilizer, similar to other chemotherapy agents like taxanes. By binding to microtubules, TPI-287 stabilizes them and prevents their depolymerization, disrupting cellular processes like mitosis and ultimately leading to cancer cell death. It has been investigated for use in various cancers, including non-small cell lung cancer, glioblastoma, and other solid tumors. Preclinical studies and early clinical trials have shown promise in its ability to overcome resistance to other chemotherapy drugs. However, further studies are needed to assess its safety, efficacy, and potential clinical applications.