For research use only. Not for therapeutic Use.
TPN729MA (TPN729 maleate) is a selective phosphodiesterase type 5 (PDE5) inhibitor with an IC50 value of 2.28 nM. TPN729MA affects erectile function and it can be used for the research of erectile dysfunction[1].
TPN729MA (1.25, 2.5 and 5.0 mg/kg; intraduodenal injection, once) increases intracavernous pressure/blood pressure (ICP/BP) with the dose of 5.0 mg/kg at all time points and with the dose of 2.5 mg/kg at 75, 90, 105, and 120 minutes time points[1].
TPN729MA (5.0 μg/kg, i.v., once) significantly increases ICP and ICP/BP of male Beagle dogs[1].
| Catalog Number | I041821 |
| CAS Number | 1422955-52-9 |
| Synonyms | (Z)-but-2-enedioic acid;N-methyl-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxy-N-(2-pyrrolidin-1-ylethyl)benzenesulfonamide |
| Molecular Formula | C29H40N6O8S |
| Purity | ≥95% |
| InChI | InChI=1S/C25H36N6O4S.C4H4O4/c1-5-9-20-22-23(30(4)28-20)25(32)27-24(26-22)19-17-18(10-11-21(19)35-16-6-2)36(33,34)29(3)14-15-31-12-7-8-13-31;5-3(6)1-2-4(7)8/h10-11,17H,5-9,12-16H2,1-4H3,(H,26,27,32);1-2H,(H,5,6)(H,7,8)/b;2-1- |
| InChIKey | CNCJOFPBSNINND-BTJKTKAUSA-N |
| SMILES | CCCC1=NN(C2=C1N=C(NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N(C)CCN4CCCC4)OCCC)C.C(=CC(=O)O)C(=O)O |
| Reference | [1]. Wang Z, et al. The selectivity and potency of the new PDE5 inhibitor TPN729MA. J Sex Med. 2013 Nov;10(11):2790-7. |
