Tr-PEG4-OH

• CAT Number: I017131
• CAS Number: 125274-16-0
• Molecular Formula: C₂₇H₃₂O₅
• Molecular Weight: 436.54
• Purity: ≥95%
• Target: PROTAC Linkers

Tr-PEG4-OH (CAT: I017131) is a non-cleavable 4-unit polyethylene glycol (PEG) linker commonly used in the synthesis of antibody-drug conjugates (ADCs). This linker is designed to attach a cytotoxic drug molecule to an antibody, allowing for targeted delivery of the drug to specific cells. The non-cleavable nature of this linker ensures stable attachment between the antibody and the drug, reducing the likelihood of premature drug release in circulation. Tr-PEG4-OH offers a balance between stability and efficacy in ADC development, making it a valuable tool in the field of targeted cancer therapy.

Reference

[1]. Zhang Q, et al. Synthesis of a library of propargylated and PEGylated α-hydroxy acids toward “clickable” polylactides via hydrolysis of cyanohydrin derivatives. J Org Chem. 2014 Oct 17;79(20):9546-55.