Trabectedin

• CAT Number: I000554
• CAS Number: 114899-77-3
• Molecular Formula: C39H43N3O11S
• Molecular Weight: 761.84
• Purity: ≥95%
• Target: Metabolic Enzyme/Protease
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IC50: 0.1-3.7 nM (breast cancer cell lines)
• IUPAC Name: [(1R,2R,3R,11S,12S,14R,26R)-5,6',12-trihydroxy-6,7'-dimethoxy-7,21,30-trimethyl-27-oxospiro[17,19,28-trioxa-24-thia-13,30-diazaheptacyclo[12.9.6.13,11.02,13.04,9.015,23.016,20]triaconta-4(9),5,7,15,20,22-hexaene-26,1'-3,4-dihydro-2H-isoquinoline]-22-yl] acetate
• InChI: InChI=1S/C39H43N3O11S/c1-16-9-20-10-22-37(46)42-23-13-50-38(47)39(21-12-25(48-5)24(44)11-19(21)7-8-40-39)14-54-36(30(42)29(41(22)4)26(20)31(45)32(16)49-6)28-27(23)35-34(51-15-52-35)17(2)33(28)53-18(3)43/h9,11-12,22-23,29-30,36-37,40,44-46H,7-8,10,13-15H2,1-6H3/t22-,23-,29+,30+,36+,37-,39+/m0/s1
• InChIKey: PKVRCIRHQMSYJX-AIFWHQITSA-N
• SMILES: CC1=CC2=C([C@@H]3[C@@H]4[C@H]5C6=C(C(=C7C(=C6[C@@H](N4[C@H]([C@H](C2)N3C)O)COC(=O)[C@@]8(CS5)C9=CC(=C(C=C9CCN8)O)OC)OCO7)C)OC(=O)C)C(=C1OC)O

Trabectedin (Cat No.:I000554) is a chemotherapeutic agent derived from the marine organism Ecteinascidia turbinata. It functions by binding to the DNA in cells, causing structural distortions that interfere with DNA replication and transcription, ultimately leading to apoptosis. Trabectedin has shown efficacy in treating various types of cancer, particularly soft tissue sarcomas and ovarian cancer. It is considered an effective option for tumors that are resistant to conventional chemotherapy. Trabectedin’s ability to target both tumor cells and their microenvironment, including immune cells, is part of its unique mechanism of action.