For research use only. Not for therapeutic Use.
Tradipitant (CAT: I009531), also referred to as VLY-686 and LY686017, is a second-generation neurokinin-1 receptor antagonist. It has demonstrated efficacy in preclinical anxiety models, suggesting its potential as a therapeutic option for anxiety-related conditions. Furthermore, Tradipitant has shown promise as a potential treatment for alcoholism, highlighting its potential role in addressing addictive behaviors.
| Catalog Number | I009531 |
| CAS Number | 622370-35-8 |
| Molecular Formula | C28H16ClF6N5O |
| Purity | ≥95% |
| Target | NK1 receptor antagonist |
| Solubility | Soluble in DMSO, not in water |
| Storage | 0 - 4 °C for short term, or -20 °C for long term |
| InChI | InChI=1S/C28H16ClF6N5O/c29-22-6-2-1-4-20(22)26(41)21-5-3-9-37-23(21)24-25(17-7-10-36-11-8-17)40(39-38-24)15-16-12-18(27(30,31)32)14-19(13-16)28(33,34)35/h1-14H,15H2 |
| InChIKey | CAVRKWRKTNINFF-UHFFFAOYSA-N |
| SMILES | O=C(C1=CC=CN=C1C2=C(C3=CC=NC=C3)N(CC4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4)N=N2)C5=CC=CC=C5Cl |
| Reference | </br>1: Gackenheimer SL, Gehlert DR. In vitro and ex vivo autoradiography of the NK-1 antagonist [³H]-LY686017 in Guinea pig brain. Neuropeptides. 2011 Apr;45(2):157-64. doi: 10.1016/j.npep.2011.01.003. Epub 2011 Feb 4. PubMed PMID: 21295853.</br>2: Tauscher J, Kielbasa W, Iyengar S, Vandenhende F, Peng X, Mozley D, Gehlert DR, Marek G. Development of the 2nd generation neurokinin-1 receptor antagonist LY686017 for social anxiety disorder. Eur Neuropsychopharmacol. 2010 Feb;20(2):80-7. doi: 10.1016/j.euroneuro.2009.10.005. Epub 2009 Dec 16. PubMed PMID: 20018493.</br>3:Kuehn BM. Findings on alcohol dependence point to promising avenues for targeted therapies. JAMA. 2009 Apr 22;301(16):1643-5. doi: 10.1001/jama.2009.535. PubMed PMID: 19383946. |
