For research use only. Not for therapeutic Use.
<em>trans</em>-<wbr></wbr>3’-<wbr></wbr>Hydroxycotinine (3HC) is a product of CYP2A6 metabolism of the primary nicotine metabolite, cotinine (Item No. <span class=/itemid/>15314</span>). Cotinine has a longer metabolic half-<wbr></wbr>life compared to 3HC (16 hours <em>vs.</em> 5 hours). The ratio of 3HC to cotinine, termed the nicotine metabolite ratio, correlates with nicotine clearance from the body and is used as a biomarker of CYP2A6 activity. This measure of nicotine metabolism has been used to study tobacco and secondhand smoke exposure as well as to develop pharmacological intervention strategies for smoking cessation.
| Catalog Number | R000126 |
| CAS Number | 34834-67-8 |
| Synonyms | (3R,5S)-3-Hydroxy-1-methyl-5-(3-pyridinyl)-2-pyrrolidinone;?(3’R,5’S)-3’-Hydroxycotinine; Hydroxycotinine; (3S-trans)-3-Hydroxycotinine; |
| Molecular Formula | C10H12N2O2 |
| Purity | ≥95% |
| Target | Endogenous Metabolite |
| Storage | -20°C |
| InChIKey | XOKCJXZZNAUIQN-IENPIDJESA-N |
