For research use only. Not for therapeutic Use.
trans-Clopenthixol dihydrochloride(CAT: I040756) is a typical antipsychotic drug belonging to the thioxanthene class, structurally related to chlorprothixene. It acts primarily as a dopamine D₂ receptor antagonist, with additional antagonistic activity at serotonin (5-HT₂) and histamine (H₁) receptors. This receptor profile contributes to its antipsychotic, sedative, and anxiolytic effects. The trans-isomer is considered the active form, and the dihydrochloride salt enhances water solubility for clinical and research use. trans-Clopenthixol dihydrochloride is used in research studying dopaminergic signaling, schizophrenia, and other psychotic disorders, as well as in evaluating the pharmacological effects of D₂ receptor antagonism.
| CAS Number | 58045-22-0 |
| Synonyms | 2-[4-[(3E)-3-(2-chlorothioxanthen-9-ylidene)propyl]piperazin-1-yl]ethanol;dihydrochloride |
| Molecular Formula | C22H27Cl3N2OS |
| Purity | ≥95% |
| IUPAC Name | 2-[4-[(3E)-3-(2-chlorothioxanthen-9-ylidene)propyl]piperazin-1-yl]ethanol;dihydrochloride |
| InChI | InChI=1S/C22H25ClN2OS.2ClH/c23-17-7-8-22-20(16-17)18(19-4-1-2-6-21(19)27-22)5-3-9-24-10-12-25(13-11-24)14-15-26;;/h1-2,4-8,16,26H,3,9-15H2;2*1H/b18-5+;; |
| InChIKey | LPWNZMIBFHMYMX-MONHGIHASA-N |
| SMILES | C1CN(CCN1CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl)CCO.Cl.Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
