trans-PX20606

• CAT Number: I008918
• CAS Number: 1268244-85-4
• Molecular Formula: C29H22Cl3NO4
• Molecular Weight: 554.85
• Purity: ≥95%

PX20606 trans racemate (PX-102 trans racemate) is a FXR agonist with EC50s of 32 and 34 nM for FXR in FRET and M1H assay, respectively[1].

Reference

[1]. Kinzel O, et al. Novel substituted isoxazole FXR agonists with cyclopropyl, hydroxycyclobutyl and hydroxyazetidinyl linkers: Understanding and improving key determinants of pharmacological properties. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3746-53.
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