trans-Trimethoxyresveratrol

• CAT Number: I002703
• CAS Number: 22255-22-7
• Molecular Formula: C17H18O3
• Molecular Weight: 270.32
• Purity: ≥95%
• Synonyms: (E)-5-[2-(4-hydroxyphenyl)ethenyl]-1,3-benzene diol
• Target: NF-κB
• Solubility: 100 mM in DMSO
• Storage: 2-8°C
• IUPAC Name: 1,3-dimethoxy-5-[(E)-2-(4-methoxyphenyl)ethenyl]benzene
• InChI: InChI=1S/C17H18O3/c1-18-15-8-6-13(7-9-15)4-5-14-10-16(19-2)12-17(11-14)20-3/h4-12H,1-3H3/b5-4+
• InChIKey: GDHNBPHYVRHYCC-SNAWJCMRSA-N
• SMILES: COC1=CC=C(C=C1)C=CC2=CC(=CC(=C2)OC)OC

Trans-Trimethoxyresveratrol（Cat No.:I002703） is a derivative of Resveratrol (RSV), a natural polyphenolic compound found in various plants. It has been suggested that Trans-Trimethoxyresveratrol may exhibit stronger anti-inflammatory, antiangiogenic, and vascular-disrupting properties compared to resveratrol. These enhanced effects are attributed to the presence of three methoxy groups in its structure. As an anti-inflammatory agent, Trans-Trimethoxyresveratrol holds potential for managing inflammatory conditions. Its antiangiogenic and vascular-disrupting activities may have implications for inhibiting the growth and development of new blood vessels in cancer treatment and other angiogenesis-related diseases.

Reference

[1]. Alex, D. et al. Resveratrol derivative, trans-3,5,4/’-trimethoxystilbene, exerts antiangiogenic and vascular-disrupting effects in zebrafish through the downregulation of VEGFR2 and cell-cycle modulation. Journal of cellular biochemistry 109, 339-346, doi:10.1002/jcb.22405 (2010)