Transergan free base

• CAT Number: I037459
• CAS Number: 82-00-8
• Molecular Formula: C19H23ClN2O2S
• Molecular Weight: 378.92
• Purity: 98%
• Synonyms: Transergan; Novazine; Transergan Free Base
• Solubility: To be determined
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 10H-Phenothiazine-10-carboxylic acid, 2-(diethylamino)ethyl ester, monohydrochloride
• InChI: InChI=1S/C19H22N2O2S.ClH/c1-3-20(4-2)13-14-23-19(22)21-15-9-5-7-11-17(15)24-18-12-8-6-10-16(18)21;/h5-12H,3-4,13-14H2,1-2H3;1H
• InChIKey: FOQGDCBIMVXYSR-UHFFFAOYSA-N
• SMILES: O=C(N1C2=C(C=CC=C2)SC3=CC=CC=C13)OCCN(CC)CC.[H]Cl

Transergan free base (Cat No.: I037459) is a neuroactive compound studied for its potential effects on the central nervous system. It is structurally related to antihistamines and neuroleptics, suggesting possible applications in sedation, anxiolysis, or antipsychotic therapy. While its precise mechanism of action remains under investigation, Transergan has been explored for its influence on neurotransmitter systems, particularly histaminergic and dopaminergic pathways. Research into Transergan free base contributes to understanding its pharmacological profile and potential therapeutic use in neurological and psychiatric disorders.

Reference

1: ELIASSON S, TEJNING S. Clinical trials of transergan in the parkinsonian syndrome. Acta Med Scand. 1956 Jun 9;154(5):375-9. doi: 10.1111/j.0954-6820.1956.tb14332.x. PMID: 13326279.
2: JOHNSON SR. Transergan, ett nytt spasmolyticum; klinisk prövning [Transergan, a new spasmolytic; clinical trial]. Nord Med. 1955 Feb 17;53(7):265-7. Swedish. PMID: 14356481.
3: WIEDLING S. Pharmacological and toxicological studies on beta- diethylaminoethyl phenothiazine-10-carboxylate hydrochloride, transergan, a new spasmolytic and anti-parkinsonism agent. Acta Pharmacol Toxicol (Copenh). 1957;13(1):59-79. doi: 10.1111/j.1600-0773.1957.tb00239.x. PMID: 13381503.
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