For research use only. Not for therapeutic Use.
Transketolase-IN-4 is a potent transketolase inhibitor (IC50=3.9 μM). Transketolase-IN-4 inhibits tumor cell proliferation of SW620, LS174T, and MIA PaCa-2. Transketolase-IN-4 is a possible Mycobacterium tuberculosis DXS inhibitor, with an IC50 value of 114.1 μM[1][2].
| Catalog Number | I041705 |
| CAS Number | 419547-73-2 |
| Synonyms | 5-benzyl-3-(4-chlorophenyl)-1H-pyrazolo[1,5-a]pyrimidin-7-one |
| Molecular Formula | C19H14ClN3O |
| Purity | ≥95% |
| InChI | InChI=1S/C19H14ClN3O/c20-15-8-6-14(7-9-15)17-12-21-23-18(24)11-16(22-19(17)23)10-13-4-2-1-3-5-13/h1-9,11-12,21H,10H2 |
| InChIKey | FIFAUXGBTKHTIJ-UHFFFAOYSA-N |
| SMILES | C1=CC=C(C=C1)CC2=CC(=O)N3C(=N2)C(=CN3)C4=CC=C(C=C4)Cl |
| Reference | [1]. Du MX, et al. Identification of novel small-molecule inhibitors for human transketolase by high-throughput screening with fluorescent intensity (FLINT) assay. J Biomol Screen. 2004 Aug;9(5):427-33. [2]. Mao J, et al. Structure-activity relationships of compounds targeting mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate synthase. Bioorg Med Chem Lett. 2008 Oct 1;18(19):5320-3. |
