Trastuzumab emtansine

• CAT Number: I037463
• CAS Number: 1018448-65-1
• Purity: 98%
• Synonyms: Trastuzumab emtansine; ado-trastuzumab emtansine; Kadcyla; T-DM1; T-DM-1; T-DM 1
• Solubility: To be determined
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: N2'-(3-((1-((4-carboxycyclohexyl)methyl)-2,5-dioxo-3-pyrrolidinyl)thio)-1-oxopropyl)-N2'-deacetylmaytansine
• SMILES: [*]NC([C@@H]1CC[C@H](CC1)CN2C(CC(C2=O)SCCC(N([C@H](C(O[C@H]3CC(N(c4c(Cl)c(OC)cc(C/C(C)=C/C=C/[C@H]([C@]5(C[C@@H]([C@H]([C@@H]6O[C@@]36C)C)OC(N5)=O)O)OC)c4)C)=O)=O)C)C)=O)=O)=O

Trastuzumab emtansine (Cat.No:I037463) also known as ado-trastuzumab emtansine and sold under the trade name Kadcyla, is an antibody-drug conjugate consisting of the humanized monoclonal antibody trastuzumab covalently linked to the cytotoxic agent DM1.

Reference

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