TREM-1 inhibitory peptide GF9

For research use only. Not for therapeutic Use.

  • CAT Number: I040139
  • CAS Number: 1289375-12-7
  • Molecular Formula: C49H76N10O12
  • Molecular Weight: 997.19
  • Purity: ≥95%
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TREM-1 inhibitory peptide GF9 (Cat No.: I040139) is a synthetic peptide designed to block the triggering receptor expressed on myeloid cells-1 (TREM-1), a key regulator of inflammation. TREM-1 is involved in amplifying the immune response during infection and inflammation. By inhibiting TREM-1, GF9 helps to reduce excessive inflammatory responses, making it a potential therapeutic for conditions like sepsis, autoimmune diseases, and chronic inflammatory disorders. Preclinical studies suggest GF9 can attenuate inflammation and promote immune system regulation without compromising pathogen defense.


CAS Number 1289375-12-7
Synonyms

(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-aminoacetyl)amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-3-methylbutanoyl]amino]-3-phenylpropanoic acid

Molecular Formula C49H76N10O12
Purity ≥95%
InChI InChI=1S/C49H76N10O12/c1-28(2)21-34(54-44(65)36(52-40(62)25-51)23-31-15-9-7-10-16-31)43(64)58-38(26-60)46(67)53-33(19-13-14-20-50)42(63)57-39(27-61)47(68)55-35(22-29(3)4)45(66)59-41(30(5)6)48(69)56-37(49(70)71)24-32-17-11-8-12-18-32/h7-12,15-18,28-30,33-39,41,60-61H,13-14,19-27,50-51H2,1-6H3,(H,52,62)(H,53,67)(H,54,65)(H,55,68)(H,56,69)(H,57,63)(H,58,64)(H,59,66)(H,70,71)/t33-,34-,35-,36-,37-,38-,39-,41-/m0/s1
InChIKey MNVMEIMCBGNQIJ-YEFFYANISA-N
SMILES CC(C)CC(C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CO)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CC2=CC=CC=C2)NC(=O)CN
Reference

[1]. Zu T Shen, et al. Rationally designed ligand-independent peptide inhibitors of TREM-1 ameliorate collagen-induced arthritis. J Cell Mol Med. 2017 Oct;21(10):2524-2534.
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