TREM-1 inhibitory peptide GF9

• CAT Number: I040139
• CAS Number: 1289375-12-7
• Molecular Formula: C49H76N10O12
• Molecular Weight: 997.19
• Purity: ≥95%
• Synonyms: (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-aminoacetyl)amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-3-methylbutanoyl]amino]-3-phenylpropanoic acid
• InChI: InChI=1S/C49H76N10O12/c1-28(2)21-34(54-44(65)36(52-40(62)25-51)23-31-15-9-7-10-16-31)43(64)58-38(26-60)46(67)53-33(19-13-14-20-50)42(63)57-39(27-61)47(68)55-35(22-29(3)4)45(66)59-41(30(5)6)48(69)56-37(49(70)71)24-32-17-11-8-12-18-32/h7-12,15-18,28-30,33-39,41,60-61H,13-14,19-27,50-51H2,1-6H3,(H,52,62)(H,53,67)(H,54,65)(H,55,68)(H,56,69)(H,57,63)(H,58,64)(H,59,66)(H,70,71)/t33-,34-,35-,36-,37-,38-,39-,41-/m0/s1
• InChIKey: MNVMEIMCBGNQIJ-YEFFYANISA-N
• SMILES: CC(C)CC(C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CO)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CC2=CC=CC=C2)NC(=O)CN

TREM-1 inhibitory peptide GF9 (Cat No.: I040139) is a synthetic peptide designed to block the triggering receptor expressed on myeloid cells-1 (TREM-1), a key regulator of inflammation. TREM-1 is involved in amplifying the immune response during infection and inflammation. By inhibiting TREM-1, GF9 helps to reduce excessive inflammatory responses, making it a potential therapeutic for conditions like sepsis, autoimmune diseases, and chronic inflammatory disorders. Preclinical studies suggest GF9 can attenuate inflammation and promote immune system regulation without compromising pathogen defense.

Reference

[1]. Zu T Shen, et al. Rationally designed ligand-independent peptide inhibitors of TREM-1 ameliorate collagen-induced arthritis. J Cell Mol Med. 2017 Oct;21(10):2524-2534.
[Content Brief]