Tretinoin

• CAT Number: A000187
• CAS Number: 302-79-4
• Molecular Formula: C20H28O2
• Molecular Weight: 300.40
• Purity: ≥95%
• Synonyms: All-trans Retinoic Acid
• Target: RARs
• Solubility: >11.9mg/mL in DMSO
• Storage: 3 years -20C powder
• IUPAC Name: (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoic acid
• InChI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+
• InChIKey: SHGAZHPCJJPHSC-YCNIQYBTSA-N
• SMILES: CC1=C(C(CCC1)(C)C)/C=C/C(=C/C=C/C(=C/C(=O)O)/C)/C

Tretinoin（Cat No.:A000187）, also known as all-trans retinoic acid, is a derivative of vitamin A widely used in dermatology to treat acne and photoaged skin. By promoting cell turnover and preventing the formation of microcomedones, tretinoin clears pores and reduces acne breakouts. It also stimulates collagen production, improving skin texture and reducing fine lines, making it effective for anti-aging treatments. Tretinoin is used in oncology as well, particularly in the treatment of acute promyelocytic leukemia (APL), where it induces differentiation of malignant cells. Its versatility makes tretinoin a valuable therapeutic agent in both dermatology and oncology.

Reference

1:Clindamycin phosphate-tretinoin combination gel revisited: status report on a specific formulation used for acne treatment. Del Rosso JQ.Cutis. 2017 Mar;99(3):179-183. PMID: 28398420
2:Successful treatment to a tretinoin/clindamycin gel in a late onset of nevus comedonicus. Capusan TM, Chicharro P, Rodriguez-Jimenez P, Martinez-Mera C, Urquía A, Aragüés M, de Argila D.Dermatol Ther. 2017 Mar 14. doi: 10.1111/dth.12486. [Epub ahead of print] No abstract available. PMID: 28295844
3:Evaluation of Structural Isomers, Molecular Interactions, Reactivity Descriptors, and Vibrational Analysis of Tretinoin. Karthick T, Tandon P, Singh S.Anal Sci. 2017;33(1):83-87. doi: 10.2116/analsci.33.83. PMID: 28070082 Free Article
4:Combined therapy in vulvar lichen sclerosus: does topical tretinoin improve the efficacy of mometasone furoate? Borghi A, Minghetti S, Toni G, Virgili A, Corazza M.J Dermatolog Treat. 2017 Jan 8:1-8. doi: 10.1080/09546634.2016.1277178. [Epub ahead of print] PMID: 28024127
5:Comparison of long-pulsed alexandrite laser and topical tretinoin-ammonium lactate in axillary acanthosis nigricans: A case series of patients in a before-after trial. Ehsani A, Noormohammadpour P, Goodarzi A, Mirshams Shahshahani M, Hejazi SP, Hosseini E, Azizpour A.Caspian J Intern Med. 2016 Fall;7(4):290-293. PMID: 27999648 Free PMC Article
6:Evaluation of salicylic acid peeling in comparison with topical tretinoin in the treatment of postinflammatory hyperpigmentation. Mohamed Ali BM, Gheida SF, El Mahdy NA, Sadek SN.J Cosmet Dermatol. 2017 Mar;16(1):52-60. doi: 10.1111/jocd.12301. Epub 2016 Dec 15. PMID: 27976510
7:Beard hair density increase. A possible role of topical tretinoin application? Vestita M, Giudice G, Bonamonte D, Apruzzi D, Filoni A.Dermatol Ther. 2016 Nov 25. doi: 10.1111/dth.12450. [Epub ahead of print] No abstract available. PMID: 27886445
8:Iontophoresis with topical 0.05% tretinoin for the management of recalcitrant palmar psoriasis: A report of two cases. Bubna AK.Indian J Dermatol Venereol Leprol. 2017 Jan-Feb;83(1):119-121. doi: 10.4103/0378-6323.193614. No abstract available. PMID: 27852991 Free Article
9:A Prospective Split-Face Comparative Study of Periorbital Wrinkle Treatments: Fractional Erbium-Doped Yttrium Aluminum Garnet Laser, Intense Pulsed Light, and Topical 0.1% Tretinoin Cream. Park SE, Kim SS, Kim CW, Her Y.Ann Dermatol. 2016 Oct;28(5):650-652. Epub 2016 Sep 30. No abstract available. PMID: 27746652 Free PMC Article
10:Arsenic Trioxide and Tretinoin (AsO/ATRA) for Acute Promyelocytic Leukemia (APL). Damery E, Solimando DA Jr, Waddell JA.Hosp Pharm. 2016 Sep;51(8):628-632. PMID: 27698500