TRH free acid

• CAT Number: I009875
• CAS Number: 24769-58-2
• Molecular Formula: C16H21N5O5
• Molecular Weight: 363.37
• Purity: ≥95%
• Synonyms: TRH free acid; Deamido-TRH; Pglu-his-pro; Pyroglutamyl-histidyl-proline; TRH-deamido. Thyrotropin-releasing hormone, deamido-.;((S)-5-oxopyrrolidine-2-carbonyl)-L-histidyl-L-proline
• Solubility: Soluble in DMSO
• Storage: 0 - 4 °C for short term, or -20 °C for long term

TRH free acid (thyrotropin-releasing hormone) (Cat No.: I009875) is a tripeptide hormone composed of pyroglutamyl-histidyl-proline, functioning as a key regulator in the hypothalamic-pituitary-thyroid axis. It stimulates the anterior pituitary to release thyroid-stimulating hormone (TSH), which in turn regulates thyroid hormone production. Beyond endocrine function, TRH also acts as a neuromodulator in the central nervous system, influencing mood, arousal, and autonomic functions. The free acid form is used in research to study hormone activity, neurological functions, and potential therapeutic applications in metabolic and neurodegenerative disorders.

Reference

1:Endocr Regul. 1991 Jun;25(1-2):134-8. Thyroliberin (TRH) and TRH free acid (TRH-OH) present in milk do not originate from local synthesis in mammary gland.Strbák V,Giraud P,Resetková E,Ouafik LH,Dutour A,Oliver C,Povazanová K,Randuskovà A, PMID: 1958827 Abstract: Hypothalamic hormones represent a peculiar group of hormones present in milk in surprisingly high concentrations. High levels of these neuropeptides raised the question of their origin. The hypothesis suggesting local synthesis of TRH in the mammary gland was, therefore, tested. Acid extracts of human milk contained TRH and TRH-OH immunoreactivity. RIA determinations at various purification steps revealed that only a part of the immunoreactivity may represent authentic peptides. No high molecular weight TRH precursor could be demonstrated upon a sequential enzymatic treatment of human milk and rat mammary gland extracts. Exploration of rat mammary gland tissue for TRH mRNA showed that the TRH gene is not expressed in the mammary gland. Rat mammary gland homogenates were able to deamidate exogenous TRH to TRH-OH.CONCLUSION: TRH is not synthesized in the mammary gland via a high molecular weight precursor. It is likely that the TRH-free acid in milk (demonstrated for the first time in this product) originates from TRH deamidation in mammary gland cells during TRH transport from the blood.