TRIA-662-d3

• CAT Number: I041825
• CAS Number: 1218993-18-0
• Molecular Formula: C7H6D3ClN2O
• Molecular Weight: 175.63
• Purity: ≥95%
• Synonyms: 1-(trideuteriomethyl)pyridin-1-ium-3-carboxamide;chloride
• InChI: InChI=1S/C7H8N2O.ClH/c1-9-4-2-3-6(5-9)7(8)10;/h2-5H,1H3,(H-,8,10);1H/i1D3
• InChIKey: BWVDQVQUNNBTLK-NIIDSAIPSA-N
• SMILES: C[N+]1=CC=CC(=C1)C(=O)N.[Cl-]

TRIA-662-d3 is the deuterium labeled TRIA-662[1]. TRIA-662 (1-Methylnicotinamide chloride) is an endogenous metabolite. TRIA-662 shows antithrombotic and anti-inflammatory activities[2].
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Reference

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.
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[2]. A M Kolodziejczyk, et al. Nanomechanical sensing of the endothelial cell response to anti-inflammatory action of 1-methylnicotinamide chloride. Int J Nanomedicine. 2013;8:2757-67.
 [Content Brief]